Elizabeth Whitmore lived to the remarkable age of 117. Researchers believe her extraordinary lifespan reveals how ageing and illness can sometimes remain separate. Whitmore, recognised as the worlds oldest person before passing away last year in England, may have had a biological age far younger than her years, according to an analysis of her genetic makeup.
Scientists and the public have long been intrigued by supercentenariansthose who reach 110 or olderand what their longevity teaches us about healthy ageing. Before her death in August 2024, Whitmore allowed a team of British researchers to study her. At 116, they collected samples of her blood, saliva, urine, and stool to examine her genetics and gut bacteria, comparing them to larger groups of elderly individuals.
Her results showed some expected signs of ageing, including a weakened immune system and high cholesterol. Yet she also had surprisingly low inflammation, a “rejuvenated” gut microbiome, and an epigenomechanges affecting gene activitythat appeared much younger.
Researchers described Whitmore as “a truly exceptional case,” noting unusual genetic variants that seemed to shield her from common illnesses like heart disease, diabetes, and neurodegenerative conditions such as Alzheimers and Parkinsons. Their findings, published in *Cell Reports Medicine*, provide new insights into healthy ageing, suggesting potential biomarkers and strategies to extend life.
While genetics likely played a key role, the team also investigated her lifestyle. Whitmore ate three yoghurts daily, which may have supported her gut health and weight. She followed a balanced diet, maintained good sleep patterns, stayed active, and enjoyed strong mental well-being.
She also led a socially engaged life, enjoying reading, playing the piano, and gardeninga well-rounded existence that may have contributed to her longevity.
“These findings demonstrate that ageing and disease can, in some cases, remain distinct,” the researchers noted, “challenging the assumption that they are always intertwined.”
